From: Detection of autoantibodies in a point-of-care rheumatology setting
Symptom | Positive test result | Disease |
---|---|---|
Airway problems | ||
 Hemoptysis | Anti-dsDNA, other lupus serologies | Alveolar hemorrhage in SLE |
 Airflow obstruction | Anti-CCP, RF | Cricoarytenoid arthritis in rheumatoid arthritis (RA) |
 Mucopurulent rhinorrhea; subglottic stenosis; hypopharyngeal ulcerations | Anti-neutrophil cytoplasmic antibodies (ANCA, MPO or PR3) | Wegener’s granulomatosis |
 Stridor, laryngotracheal strictures | Anti-type II collagen | Relapsing polychondritis |
 Acute pneumonitis | Anti-dsDNA, other lupus serologies | SLE |
Pulmonary–renal problems | ||
 Pulmonary hemorrhage and acute renal failure | Anti-GBM, MPO-ANCA, PR3-ANCA | Goodpasture’s syndrome; systemic vasculitis |
Neuropsychiatric problems | ||
 Encephalopathy, psychosis, focal central nervous system disease | Anti-N-methyl-d-aspartate receptor (NMDA-R), anti-ribosomal P antibodies, antiphospholipid antibodies | Neuropsychiatric SLE, antiphospholipid syndrome |
 Weakness, paralysis, bilateral sensory deficit, impaired sphincter control | Lupus serologies | Transverse myelitis in SLE |
 Seizures | Anti-dsDNA, other lupus serologies | Lupus cerebritis |
Thromboembolic problems | ||
 DVT, pulmonary thromboembolism, fetal loss, retinal artery occlusion | Anti-phospholipid antibodies | Antiphospholipid syndrome |
Neuromuscular problems | ||
 Progressive symmetric muscle weakness; dysphagia; dysphonia | Anti-Jo-1, other myositis-specific autoantibodies | Dermatomyositis, polymyositis |
 Unusual weakness and hypokalemia | Anti-Ro/SSA; anti-La/SSB | Sjogren’s syndrome hypokalemic paralysis |
Cardiac problems | ||
 Pleuritic or positional chest pain, dyspnea, tachycardia | Anti-dsDNA, other lupus serologies, Anti-phospholipid antibodies | SLE pleuro-pericarditis, pericardial tamponade |
 Congenital heart block; neonatal carditis | Anti-Ro/SSA; anti-La/SSB | Neonatal SLE |
Renal problems | ||
 Rapidly progressive renal failure | MPO-ANCA, PR3-ANCA, anti-dsDNA and other lupus serologies, anti-phospholipid antibodies | Microscopic polyangiitis, WG, lupus nephritis, catastrophic antiphospholipid syndrome |
 Accelerated hypertension | Anti-Scl-70; anti-centromeres, anti-RNA-Polymerase III | Renal crisis in systemic sclerosis |
Joint problems | ||
 Pain, stiffness, swelling with symptoms of systemic disease | Anti-CCP, RF and lupus serologies | RA, SLE |
Ocular problems | ||
 Red, painful, photophobic eye | RF, anti-CCP, lupus serologies | RA, Behcet’s, juvenile RA, SLE |
Gastrointestinal problems | ||
 Colicky abdominal pain | Lupus serologies | SLE mesenteric arteritis |
Skin problems | ||
 Petechiae, palpable purpura, hemorrhagic blisters, ulcerations and gangrene | SLE and RA serologies | SLE, rheumatoid vasculitis |
 Neonatal skin rash | Anti-Ro/SSA, anti-La/SSB | Neonatal lupus |
Hematological problems | ||
 Anemia, thrombocytopenia, leukopenia | Anti-DNA and lupus serologies; anti-erythrocyte, anti-platelet antibodies | SLE, autoimmune hemolytic anemia |
 Thrombocytopenia | Antiphospholipid antibodies | Antiphospholipid syndrome |