Table 3 Tumor-associated antigens identified from patients with HCC and their functions
From: Autoantibodies in liver disease: important clues for the diagnosis, disease activity and prognosis
Intracellular component | Autoantigens | Biological functions |
|---|---|---|
Nucleus | DNA topoisomerase II | DNA replication/transcription |
CENP-F | Mitotic function | |
HCC-1 | mRNA splicing | |
Cyclin B1 | Cell-cycle progression | |
Fibrillarin | rRNA processing | |
NOR-90/hUBF | RNA pol I transcription | |
B23 | Ribosome maturation | |
Ku86 | DNA doule-strand break repair | |
Cytoplasm | p62/IMP2 | Regulation of IGF-II mRNA |
Koc/IMP3 | Regulation of IGF-II mRNA | |
Golgi | Processing, transporting and sorting of intracellular proteins |