Table 2 Prognostic values of PBC-specific ANA
From: Autoantibodies in liver disease: important clues for the diagnosis, disease activity and prognosis
Immunofluorescent pattern | Nuclear antigens | Clinical significance |
|---|---|---|
Rim-like/membranous | gp210 nucleoporin/p62 lamin B receptor | Progression to liver failure advanced liver stage |
Multiple nuclear dots | Sp100 | Recurrent urinary tract infection |
Sp140 | Coexistence with anti-Sp100 | |
PML | Coexistence with anti-Sp100 | |
Discrete speckled | CENP-B | Progression to portal hypertension |