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TableĀ 2 Prognostic values of PBC-specific ANA

From: Autoantibodies in liver disease: important clues for the diagnosis, disease activity and prognosis

Immunofluorescent pattern

Nuclear antigens

Clinical significance

Rim-like/membranous

gp210 nucleoporin/p62 lamin B receptor

Progression to liver failure advanced liver stage

Multiple nuclear dots

Sp100

Recurrent urinary tract infection

Sp140

Coexistence with anti-Sp100

PML

Coexistence with anti-Sp100

Discrete speckled

CENP-B

Progression to portal hypertension