Table 1 Clinical significance of autoantibodies in liver disease

ANA

Histone

Type 1 AIH, PBC

H3-predominant in type 1 AIH

Chromatin

Type 1 AIH

Higher IgG levels

dsDNA

Type 1 AIH

Diseases activity, unfavorable prognosis

Centromere

PBC, type 1 AIH, HCV (rare)

Complementry marker for PBC in AMA-negative case

hnRNP

Type 1 AIH

Specific to type 1 AIH

SMA

Actin

Type 1 AIH

Diagnostic marker for type 1 AIH, unfavorable prognosis

Myosin

HCV

Vimentin

Tublin

Alcohlic liver diseases

Desmin

Anti-LKM1

CYP2D6

Type 2 AIH, HCV

Diagnostic marker for type 2 AIH

CYP2A6

HCV (rare)

Anti-LKM2

CYP2C9

Tienilic acid-included hepatitis

Anti-LKM3

UGT1A2

HDV, HCV (rare)

Anti-LC1

Formiminotransferase cyclodeaminase

Type 2 AIH, HCV

Diagnostic marker for type 2 AIH

Anti-SLA/LP

UGA supressor tRNA-associated protien

Type 1 AIH, HCV (rare)

Disease activity, relapse after drug withdrawal

pANCA

Actin

Type 1 AIH

HMG

Type 1 AIH

Lactoferrin

Type 1 AIH, PBC, PSC, HCV

50 kD myeloid-specific nuclear envelope protien

PSC, type 1 AIH

Anti-ASGPR

Asialoglycoprotein receptor

Type 1 AIH, PBC, HBV, HCV, HDV drug-induced hepatitis

Diseases activity, relapse after drug withdrawal

AMA

PDC-E2

PBC, AIH (rare), HCV (rare)

Diagnostic marker for PBC

BCOAD-E2, OGDC-E2

PBC

Specific to PBC

tTGA

Tissue transglutaminase

Celiac disease

Disease activity

ASCA

Saccharomyces cerevisiae

Type 1 AIH, PBC, PSC, celiac disease

Correlation with IgA levels

Anti-GST

Glutathione S-transferase

Type 1 AIH

Disease activity, unfavorable prognosis

Anti-GW/PB

GW/PB

PBC

Anti-CRP

CRP

HCV

Predictive marker for concurrent mixed cryoglobulinemia