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Table 2 Criteria for defining a disease as autoimmune (modified from Witebsky [13])

From: The immunofluorescence techniques in the diagnosis of endocrine autoimmune diseases

Presence of autoantibodies and/or cell-mediated events in the serum
Presence of lympho-monocyte infiltration in the target organs
Possibility of identification and isolation of autoantigens
Possibility of experimentally induction of the disease in animals by immunization with autoantigens and the transfer the disease passively by serum or lymphocytes