Table 3 Comparative performances of CLIA (Zenit RA) and ELISA tests for APS-related antibody determination
From: Routine use of Zenit RA, a novel chemiluminescent immunoanalyzer in autoimmune disease diagnosis
Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
|---|---|---|---|---|
aCL (IgG) | ||||
CLIA | 54.4 | 97.3 | 93.5 | 75 |
ELISA | 68.3 | 95.5 | 91.5 | 81 |
aCL (IgM) | ||||
CLIA | 24.1 | 95.5 | 79.2 | 64 |
ELISA | 20.2 | 97.3 | 84.2 | 63 |
aB2GP1 (IgG) | ||||
CLIA | 53 | 91 | 97.2 | 77 |
ELISA | 40 | 91 | 96.3 | 72 |
aB2GP1 (IgM) | ||||
CLIA | 20.8 | 95.1 | 75 | 63 |
ELISA | 15.2 | 98.1 | 83.3 | 65 |
At least one out of above antibodies | ||||
CLIA | 63.3 | 91.9 | 84.8 | 78 |
ELISA | 74.7 | 91.9 | 86.8 | 84 |