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Fig. 6 | Autoimmunity Highlights

Fig. 6

From: Blocking type TSH receptor antibodies

Fig. 6

In vivo effect of administration of K1-70 IgG or M22 IgG or K1-70 IgG and M22 IgG into rats. a Serum levels of K1-70 IgG following intramuscular injection of K1-70 IgG; 200 μg/rat (filled square); 100 μg/rat (filled diamond) (unsuppressed rats); negative control buffer (times symbol); mean ± SD, n = 5. b Serum levels of total T4 following intramuscular injection of K1-70 IgG; 200 μg/rat (filled square); 100 μg/rat (filled diamond) (unsuppressed rats); negative control buffer (times symbol); mean ± SD, n = 5. c Serum levels of M22 IgG following intramuscular injection of M22 IgG; 10 μg/rat (filled square); 4 μg/rat (filled diamond) (T3 suppressed rats); negative control buffer (times symbol); mean ± SD, n = 5. d Serum levels of total T4 following intramuscular injection of M22 IgG; 10 μg/rat (filled square); 4 μg/rat (filled diamond) (T3 suppressed rats); negative control buffer (times symbol); mean ± SD, n = 5. e Serum levels of total T4 following intramuscular injection of M22 IgG only at time 0 (filled square) and M22 IgG at time 0 followed by K1-70 IgG at time 3 h (filled diamond) (T3 suppressed rats); mean of n = 5 determinations. Figure is reproduced from Figs. 1, 3 and 4 in [78] The publisher for this copyrighted material is Springer and a license number 2831400304013 has been granted

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