Fig. 3
Effect of 1 μg/mL of 5C9 IgG or MAb-B2 IgG on constitutive (i.e., basal) activity of wild-type TSHR and TSHRs containing activating mutations: a wild-type TSHR. b S281I (TSHR extracellular domain). c I568T (TSHR transmembrane domain extracellular loop-2). d A623I (TSHR transmembrane domain intracellular loop-3). 2G4 is a negative control human autoantibody to thyroid peroxidase (TPO; [54]). Reprinted from reference [77]. The publisher for this copyrighted material is Mary Ann Liebert, Inc publishers