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Table 2 Serological markers of AIP in the study subjects

From: Differentiation of autoimmune pancreatitis from pancreas cancer: utility of anti-amylase and anti-carbonic anhydrase II autoantibodies

 

IgG increased

IgG4 increased

CA-II Abs positivity

AMY-α Ab positivity

AIP

58 (7/12)a

58 (7/12)b

83 (10/12)c

83 (10/12)d

CP

17 (4/23)

0 (0/23)

9 (2/23)

13 (3/23)

ICP

38 (10/26)

8 (2/26)

50 (13/26)

31 (8/26)

Acute pancreatitis

27 (3/11)

(1/11)

54 (6/11)

18 (2/11)

Pancreatic cancer

10 (2/21)

14 (3/21)

29 (6/21)

0 (0/21)

SS

67 (6/9)

0 (0/9)

67 (6/9)

23 (2/9)

T1DM

ND

7 (3/40)

32 (13/40)

22 (9/40)

Healthy subjects

0 (0/45)

2 (1/45)

8 (4/45)

2 (1/45)

  1. Results are expressed as percentage (number of positive cases/total number of cases)
  2. Ab antibodies, AIP autoimmune pancreatitis, CP chronic pancreatitis, ICP idiopathic chronic pancreatitis, ND not determined, SS Sjögren’s syndrome, T1DM type 1 diabetes mellitus
  3. aAIP versus CP: 0.03; AIP versus pancreatic cancer: 0.002; AIP versus healthy subjects: <0.0001
  4. bAIP versus CP: <0.0001; AIP versus ICP: 0.001; AIP versus acute pancreatitis: 0.013; AIP versus pancreatic cancer: 0.008; AIP versus SS: 0.005; AIP versus T1DM: <0.0001; AIP versus healthy subjects: <0.0001
  5. cAIP versus CP: <0.0001; AIP versus ICP: 0.05; AIP versus pancreatic cancer: 0.002; AIP versus T1DM: 0.002; AIP versus healthy subjects: <0.0001
  6. dAIP versus CP: <0.0001; AIP versus ICP: 0.003; AIP versus acute pancreatitis: 0.002; AIP versus pancreatic cancer: <0.0001; AIP versus SS: 0.005; AIP versus T1DM: <0.0001; AIP versus healthy subjects: <0.0001