Table 2 Myositis-associated autoantibodies and their functional activities
From: Myositis-specific autoantibodies: detection and clinical associations
Autoantibody | Autoantigen | Molecular mass (kDa) | Function of autoantigen |
|---|---|---|---|
Anti-PM/Scl | Â | Â | Â |
|  | PM/Scl-75 | 75 | RNA processing + degradation |
| Â | PM/Scl-100 | 100 | Â |
Anti-Mas | Â | Â | Â |
| Â | Serine-tRNASec-protein complex | 48 | Selenocysteine incorporation |
Anti-Ro/SS-A | Â | Â | Â |
 Anti-Ro52 | Ro52 | 52 |  |
 Anti-SS-A | Ro60 | 60 | RNA quality control |
Anti-La/SS-B | Â | Â | Â |
 Anti-SS-B | La | 48 | RNA binding + Pol III transcription |
Anti-RNP | Â | Â | Â |
| Â | U1A | 34 | Pre-mRNA splicing |
| Â | U1C | 22 | Â |
| Â | U1-70k | 70 | Â |
Anti-Wa | Peptide | 48 | Unknown |
Anti-PMS | a.o. PMS1, PMS2 | n.d. | DNA binding protein complex involved in DNA-repair |
Anti-Ku | Â | Â | Â |
| Â | Ku70 | 70 | DNA dependent protein phosphorylation |
| Â | Ku80 | 80 | Â |
Anti-Fer | Â | Â | Â |
| Â | eEF1 | Â | Translation |
Anti-KJ | Peptide | 30/34 | Translocation factor |
Anti-56K | Nuclear RNP | 56 | Unknown |