Fig. 8
From: Myositis-specific autoantibodies: detection and clinical associations
SRP mediates translocation of nascent, signal peptide-containing proteins: a schematic structure of SRP, b mechanism of protein translocation mediated by SRP. First, SRP binds to the N-terminal signal peptide of the growing peptide chain which results in elongation arrest (1). Subsequently, the ribosome/SRP complex is targeted to the SRP receptor (SR) at the ER membrane by specific sequences in the SRP proteins (2). Docking of the complex to the membrane bound translocon releases the signal peptide from the SRP complex and enables translation to continue (3). The SRP dissociates and is recycled for additional translocation events (4)