Fig. 5
From: Myositis-specific autoantibodies: detection and clinical associations
Aminoacylation of tRNA by histidyl-tRNA synthetase. The HisRS, as well as other aaRSs, catalyze the ATP-dependent esterification reaction that is needed to couple an amino acid to its cognate tRNA. Subsequently, the aminoacylated-tRNA can be used in translation. AMP adenosine monophosphate, ATP adenosine triphosphate, PPi inorganic phosphate